Until the last decade, performance of HPC architectures has been almost exclusively quantifiedby their processing power. However, energy efficiency is being recently considered as importantas raw performance and has become a critical aspect to the development of scalablesystems. These strict energy constraints guided the development of a new class of so-calledlight-weight manycore processors. This study evaluates the computing and energy performanceof two well-known irregular NP-hard problems — the Traveling-Salesman Problem (TSP) andK-Means clustering—and a numerical seismic wave propagation simulation kernel—Ondes3D—on multicore, NUMA, and manycore platforms. First, we concentrate on the nontrivial task ofadapting these applications to a manycore, specifically the novel MPPA-256 manycore processor.Then, we analyze their performance and energy consumption on those di↵erent machines.Our results show that applications able to fully use the resources of a manycore can have betterperformance and may consume from 3.8x to 13x less energy when compared to low-power andgeneral-purpose multicore processors, respectively