Total mining waste in Europe amounts to 6Gt, most of which contains iron (Fe), sulfur (S), and other toxic pollutants including metalloids and metals such as lead (Pb), arsenic (As), and zinc (Zn). To reduce pollutant fluxes from mine tailings, phytostabilization based on growing metal-tolerant plants is a common practice, notably to reduce erosive fluxes. Usually, organic amendments are also added in the mine tailing to promote plant growth. This practice as well as root growth impacts the biogeochemical properties of the tailings. They are suspected to drastically modify the microbially mediated redox reactions controlling metal fluxes but this impact still remains unclear. Combining mesocosm and microcosm experiments with a geochemical model based on simulations of microbially-mediated redox reactions thermodynamically constraints, our study evaluates the impact of assisted phytostabilization on the bioenergetic landscape of mine tailings. In mesocosm (i.e. an instrumented metric column containing homogeni