The Kédougou Kénieba Inlier (KKI) of eastern Senegal forms a typical Paleoproterozoic greenstone belt characterised by low-metamorphic sequences of volcanic rocks and volcano-sediments that have been intruded at various stages by gabbroic suites and calc-alkaline granitoids. The main structures of the KKI comprise two anastomosing structures about N–S trending shear belts that are distinguished into the western Main Transcurrent Zone (MTZ) and the eastern Senegalo-Malian shear zone system (SMSZ). These shear belts are taken to define the limits between the western Mako, the central Diale-Kéniebandi and the eastern Daléma-Kofi domains even though transitions exist between their characteristic deposition sequences. Remote sensing analysis of airborne geophysics and satellite data (Landsat, ENVI, SRTM) in combination with geological field mapping, structural analysis and geochronology suggests that the SMSZ represents a Birimian structure that records a main stage of deformation that could characterise the major transcurrent Eburnean tectonics (D2) dated from 2105 Ma (Feybesse et al., 2006a–e). This sinistral transpressive deformation marked by a major constraint oriented NNW–SSE, is accompanied by a NNE–SSW extension leading to the opening of dilational areas such as small pull-apart basins marked by local calk-alkaline volcanic sequences and several coeval intrusions of the Boboti Suite dated 2080 ± 0.9 Ma (Hirdes and Davis, 2002). A post-Birimian to pre-Neoproterozoic deformation post dates the transcurrent phase and is marked by regional N–S extension. Review of the existing Au-mineralisation models in combination with the spatial analysis of soil geochemical data suggest seven possible mineralisation styles that are related to the transpressional tectonics and coeval magmatism.