The Mediterranean region is one of the most seismically active areas in the world, an effect which is associated with the conjunction between the Eurasian and African tectonic plates, as well as the drift of other plates like the Anatolian and Aegean. On the other hand, the movements of numerous other smaller tectonic features also contribute to the complex geotectonic situation in the region. The seismic events occurring in the region comprise the shocks in the vast range of magnitude and depth, but a big percentage of all events occur in the shallower lithospheric layers with moderate strength. The studying of this group of shocks is realizable by different geophysical approaches and it contributes to the more precise determination of the plate boundaries. Moreover, the combination between different investigating methods enlarges the flexibility and reliability of the study. The present work is focused on the investigation of the advantages and disadvantages of the application and combination of different methods for examining several moderate shallow seismic events that occurred in the last 15 years in the Mediterranean. The data available for the study of the different earthquakes are InSAR, GPS and levelling measurements, seismological records, geological and tectonic information. The events used for the investigation are spread in the different parts of the Mediterranean region: Konitsa (1996), Boumerdes (2003), Lefkada (2003), L'Aquila (2009), and some others.