%0 Conference Paper %F Poster %T How solid phase extraction conditions affect suspect and non-target screening for the evaluation of surface water contamination %+ Milieux aquatiques, écologie et pollutions (UR MALY) %+ Bureau de Recherches Géologiques et Minières (BRGM) (BRGM) %+ Institut National de l'Environnement Industriel et des Risques (INERIS) %+ Laboratoire National de Métrologie et d'Essais [Trappes] (LNE ) %A Bonnefille, Bénilde %A Guillemain, C. %A Togola, Anne %A Soulier, Coralie %A Lestremau, Francois %A Léonço, Daniel %A Lardy Fontan, S. %A Cabilic, Julie %A Margoum, C. %Z AFB BRGM %< avec comité de lecture %B International conference on Emerging Contaminants 2018 (EmCon) %C Oslo, Norway %8 2018-06-25 %D 2018 %K Suspect screening %K Non-target screening %K Sample preparation %K Water quality %K Organic contaminants %Z Chemical Sciences/Analytical chemistryPoster communications %X Identifying organic contaminants present in aquatic environments is of major concern for water qualitymonitoring. New analytical and data treatment tools have been developed to meet this challenge. Thesample preparation before analyses is the first crucial step to be optimized before using suspect and nontarget-screening approaches for qualitative evaluations of water pollution by contaminants from variouschemical and usage families.As part of the action of Aquaref (www.aquaref.fr, French reference laboratory for environmentalmonitoring in the Water Framework Directive), different solid phase extraction conditions (SPE, n=3 percondition) were tested towards ultrahigh pressure liquid chromatography hyphenated to high resolutionmass spectrometry (UHPLC-HRMS) analysis. The SPE protocols varied according to the extraction phase(Oasis HLB or multilayer cartridge), the elution solvent (methanol or methanol and dichloromethane)and sample pH (pH 3 or 7). To ensure data quality, blank solvents, extracted blanks and quality control(QC) were also injected. The QC sample corresponds to a pool of 5 μL of each sample extract and isinjected repeatedly throughout the injection sequence to monitor the analytical repeatability.By suspect screening strategy, most of the investigated compounds were found in all SPE extracts. Theresults revealed the presence of contaminants such as pesticides, pharmaceuticals, sweeteners, or anticorrosiveagents. For pesticides, approved (e.g. diuron) and not approved (e.g. terbutryn) compoundswere both detected. Concerning the pharmaceuticals, drugs acting on the nervous system were mostcommon (e.g. oxazepam), as well as betablockers (e.g. metoprolol). The without any a priori non-targetapproach highlighted that the SPE conditions affect the quality and the interpretation of the data. Foreach sample preparation method tested the number of signals (features) detected varies, as does thenumber of signals associated with background noise. %G English %Z AQUAREF %L hal-01731013 %U https://brgm.hal.science/hal-01731013 %~ INERIS %~ BRGM %~ IRSTEA %~ LNE %~ AGREENIUM %~ INRAE