Local and network changes after multichannel transcranial direct current stimulation using magnetoencephalography in patients with refractory epilepsy - Institut de Neurosciences des Systèmes
Article Dans Une Revue Clinical Neurophysiology Année : 2024

Local and network changes after multichannel transcranial direct current stimulation using magnetoencephalography in patients with refractory epilepsy

Ricardo Salvador
Khoubeib Kanzari
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Francesca Pizzo
Giada Damiani
Jean-Michel Badier
Giulio Ruffini

Résumé

Objective: Non-invasive neuromodulation techniques, particularly transcranial direct current stimulation (tDCS), are promising for drug-resistant epilepsy (DRE), though the mechanisms of their efficacy remain unclear. This study aims to (i) investigate tDCS neurophysiological mechanisms using a personalized multichannel protocol with magnetoencephalography (MEG) and (ii) assess post-tDCS changes in brain connectivity, correlating them with clinical outcomes. Methods: Seventeen patients with focal DRE underwent three cycles of tDCS over five days, each consisting of 40-minute stimulations targeting the epileptogenic zone (EZ) identified via stereo-EEG. MEG was performed before and after sessions to assess functional connectivity (FC) and power spectral density (PSD),estimated at source level (beamforming). Results: Five of fourteen patients experienced a seizure frequency reduction > 50 %. Distinct PSD changes were seen across frequency bands, with reduced FC in responders and increased connectivity in non-responders (p < 0.05). No significant differences were observed between EZ network and non-involved networks. Responders also had higher baseline FC, suggesting it could predict clinical response to tDCS in DRE. Conclusions: Personalized multichannel tDCS induces neurophysiological changes associated with seizure reduction in DRE. Significance: These results provide valuable insights into tDCS effects on epileptic brain networks, informing future clinical applications in epilepsy treatment.
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hal-04874139 , version 1 (08-01-2025)

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Maeva Daoud, Samuel Medina Villalon, Ricardo Salvador, Maria Fratello, Khoubeib Kanzari, et al.. Local and network changes after multichannel transcranial direct current stimulation using magnetoencephalography in patients with refractory epilepsy. Clinical Neurophysiology, 2024, 170, pp.145-155. ⟨10.1016/j.clinph.2024.12.006⟩. ⟨hal-04874139⟩
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